Lab alum Sam Cherra (front left) reports the funding of his R01 entitled Regulation of synapse development by small GTPase cascades in Caenorhabditis elegans. He was previously funded on an K99/R00 to study the excitation/inhibition balance in neural circuits. As a former graduate student, he not only continues his successful history of funding stemming back to his F31 on PINK1 and LRRK2 in the Chu Lab, but also has successfully mentored his own graduate student through the grant-writing process! Congratulations again.
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Aaron Gusdon, who just moved to Houston as an Assistant Professor of Neurosurgery at the UT Health Science Center, received notification that his K23 will be funded by NIH!
Aaron has a long term interest in mitochondrial pathobiology and will be studying metabolic effects of aneurysmal subarachnoid hemorrhages, while continuing to practice in Neuro-Critical Care. He joins an illustrious group of lab alumni who have achieved independent funding within two years of starting their first faculty position. Charleen T. Chu, a professor of pathology at the University of Pittsburgh, won the Robbins Distinguished Educator Award from the American Society for Investigative Pathology. The award, named in honor of the late pathologist and textbook author Stanley L. Robbins, recognizes scientists who have made exemplary contributions to education.
Ed just received notification that his K08 application, entitled NMDA receptor trafficking by the autophagy regulatory protein berlin 1 will be funded!
Two of his papers have also recently been accepted -- one on mutant LRRK2 electrophysiology in BBA-Molecular Basis of Disease from his work in our lab, and a new paper from his lab on transcriptional regulation of beclin 1 complexes in Autophagy. The lecture, SOS: Mitochondrial Distress Signals in Parkinson's Disease, was preceded by the awarding of a bronze medallion by Dean Levine. A celebratory dinner banquet at the Monterey Bay Fish Grotto was attended by multiple members of the Martinez family, members of the Oury-Chu family and lab groups, and colleagues in Pathology, Neuropathology and Neurosurgery.
Click below to read what Nektarios Tavernarakis & Vassiliki Nikoletopoulou: F1000 Cell Biology, and Zu-Hang Sheng & Rajat Puri: F1000 Neuroscience had to say about our study on Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells . http://f1000.com/prime/718109987
Other studies noted by the F1000 Biology or F1000 Medicine were:
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization by Van Laar et al. in Sarah Berman's lab. Regulation of the autophagy protein LC3 by phosphorylation by Cherra et al. of the Chu lab. Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content by Bear et al. in Constance Chu's lab. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission by Dagda et al. of the Chu lab. |
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